Voyage of the Bacteria Bot :

Self-propelled microbots navigate through blood vessels.

The 1966 science-fiction movie Fantastic Voyage famously imagined using a tiny ship to combat disease inside the body. With the advent of nanotechnology, researchers are inching closer to creating something almost as fantastic. A microscopic device that could swim through the bloodstream and directly target the site of disease, such as a tumor, could offer radical new treatments. To get to a tumor, however, such a device would have to be small and agile enough to navigate through a labyrinth of tiny blood vessels, some far thinner than a human hair.

Researchers at the École Polytechnique de Montréal, in Canada, led by professor of computer engineeringSylvain Martel, have coupled live, swimming bacteria to microscopic beads to develop a self-propelling device, dubbed a nanobot. While other scientists have previously attached bacteria to microscopic particles to take advantage of their natural propelling motion, Martel's team is the first to show that such hybrids can be steered through the body using magnetic resonance imaging (MRI).

To do this, Martel used bacteria that naturally contain magnetic particles. In nature, these particles help the bacteria navigate toward deeper water, away from oxygen. "Those nanoparticles form a chain a bit like a magnetic compass needle," says Martel. But by changing the surrounding magnetic field using an extended set-up coupled to an MRI machine, Martel and his colleagues were able to make the bacteria propel themselves in any direction they wanted.

The bacteria swim using tiny corkscrewlike tails, or flagella, and these particular bacteria are faster and stronger than most, says Martel. What's more, they are just two microns in diameter--small enough to fit through the smallest blood vessels in the human body. The team treated the polymer beads roughly 150 nanometers in size with antibodies so that the bacteria would attach to them. Ultimately, the researchers plan to modify the beads so that they also carry cancer-killing drugs.